October 2009

Edition 26

October 2009

Edition 26

From R&D to solid outcomes!


Recent months have been very much taken up by the 'wind up' process. One issue in particular — managing our intellectual property (IP) — has seen our last six years' research and development investments under the microscope in terms of value.  The string of IP created is quite daunting in terms of scope, detail, long- and short-term value. This is something for which our researchers should be justly proud.

More

Clearly we have created an array of knowledge and understanding across our extensive R&D portfolio, and will no doubt leave a legacy of platform understanding and technology. This legacy will be a strong base for future sugarcane biotechnology R&D. Even more significant are the many projects that have helped our CRC meet obligations to our investors to create commercial value to Australian sugarcane.

I am not saying that the path from R&D to commercial outcomes is a smooth one. The skill sets of good scientific research and commercialisation of an end product are often very different; however, as we have seen in recent months, the benefits of the two sectors working together are enormous.

It is this 'synergy' that we have been harvesting in our CRC. As we manage our 'wind up' and commercialisation of our outputs, it continues to be critical that we successfully transition from R&D to establishing solid outcomes (defining our IP).

If you are involved in this process, I seek your continued support. I firmly believe to see the fruits of your ideas and knowledge materialise into commercial value for Australia will give you a deep sense of professional satisfaction.

Opportunity to showcase your work

Our CRC will be a principal sponsor to the 2010 ASSCT Conference to be held in Bundaberg from 11 to 14 May 2010. This event is an ideal forum for us to showcase our work to the Australian sugarcane industry's growers, millers, researchers and administrators.

More

It is essential that representatives for each of our projects make a commitment to telling the Australian sugarcane industry about our research and development, in particular tangible results to come out of our CRC.

For those projects that have previously not been represented, it is imperative that a paper and presentation is made next year. Financial assistance will be provided to those who submit papers for 2010 ASSCT.  For further information please go to the Events section of this newsletter or contact Peter Twine, ph: 3365 7502.



Carol accepts role as Senior Director in the US

Dr Carol Morris announced this month that she will move to Cooper Vision Corp (a leading contact lens company), Pleasanton, USA, where she has been offered a position as the Senior Director of Biological Sciences in the R&D Section.

More

Since 2007, Carol has headed our very successful Bioactives Project based at Southern Cross University (SCU), Lismore, where sugarcane's health enhancing and disease management compounds have been identified.

The project originally pursed possibilities for compounds found in sugarcane leaves as inhibitors of benign prostrate hyperplasia. This opportunity was ruled out and the team turned their attention to other leads they had found in screening studies, namely compounds that inhibit enzymes involved in mouth and gut breakdown of complex carbohydrates.

The SCU team have since been paramount in the development of GI-Wise™ (see this issue's 'blood sugar regulator' story) a potential basis for a range of health products that could help manage type2 diabetes.  

Prior to SCU, Carol worked for the world's second largest contact lens company, Cibavision Corp, also in the US. Cibavision was an industry partner in the Australian CRC for Eye Research and Technology. 

Carol said her new role will tackle the latest challenges in eye research and lens technology, an area in which a fresh new round of innovation is predicted: "I believe the way forward will be in developing a better understanding of the biology of the needs of the eye," she said.  

On a more personal level, by moving to the US Carol will be a lot closer to her New York-based daughter and grandson. Carol said she was looking forward to being an 'active' grandmother.  

Carol plans to keep regular contact with SCU. Our CRC wishes Carol the very best in her new ventures and would like to thank her for her invaluable contributions to our work.



Impressive interest in CRC products


Deon Goosen's recent trip to the United States is testimony to the fact that some of our major project outcomes are attracting serious interest across the globe. Deon went to the United States from Thursday 24 September to Sunday 4 October.

More

Following is some insight into his trip.

•     Metagenics discussions – Metagenics is one of the world's biggest natural alternative medications suppliers. Discussions centred on GI-Wise™. Metagenics is now seeking a Confidentiality Agreement with our CRC.

•     Formwork Company – who are keen to test BARRECOTE™. The discussions were successful, and there is an agreement in place with the CRC.

•     Cargill – discussions were had regarding GI-Wise™ and BARRECOTE™.  Different sections in Cargill are interested in GI-Wise™ and BARRECOTE™ and Confidentiality Agreements are now in place. A Material Evaluation Agreement is in place with the Cargill division interested in BARRECOTE™, and testing will occur in Germany in the near future.  Pepsi have also approached Cargill asking for an introduction to our CRC so they may discuss GI-Wise™.

•     Michelman – was introduced to our CRC by Cargill. Michelman's is one of the top five paper producers in the world. Michelman's is interested in testing BARRECOTE™, and a Material Evaluation Agreement is currently being signed.

•     Metabolix – Deon and Oliver Peoples discussed 'wind-up' plans for our CRC.



Powerful blood sugar regulators identified in sugarcane

 
As many of you know, our 'bioactives' team at SCU have identified natural glycaemic index (GI) modifiers that have the potential to dramatically lower blood sugar levels and help manage type 2 diabetes.

More

The discovery: 'a family of compounds which occur naturally in sugarcane plants and act to moderate carbohydrate absorption in the blood stream', are found in abundance in sugarcane leaves and plant matter. In laboratory trials they have been up to 125 times more effective than the major pharmaceutical equivalent.

These compounds have been broadly tested in the laboratory and recently developed as the substance GI-Wise™.  This could be used in the development of complementary medicines, as a functional food additive or nutraceutical, or as the basis of a new pharmaceutical drug. GI-Wise™ is attracting a great deal of commercial interest around the world.

News from Panama


Well the second month in Panama has come and gone. The newness of everything has faded and we now embrace our trips into the city rather than have apprehension of the unknown. Today is a strange day. A previous president died yesterday and today is a day of mourning – no one at work is the most obvious consequence of this. I went field sampling this morning and one of my sites, the Gamboa boat ramp was choc a block of four wheel drives and boat trailers. Seems like for many, like in Australia a holiday is for doing the things you like.

More

We are meeting more people and slowly learning more Spanish. Ruby and Sarah are playing with an Orchestra at one of the local middle schools so they are meeting some friends. In fact, they have gone to one of their fellow strings player's house today to spot the toucans in their backyard. I have heard lots of howler monkeys and now even seen some. The butterflies are amazing in number and variety.

Work

After two months I feel I have achieved several things with results being collected and am at the stage where I need to take stock and see what else needs to be done in the coming months to complete some things. 

The bags made last month have been successful at collecting the Guinea grass seed — need to design the experiment to test their germination. I have also harvested some pollen excluded Saccharum spontaneum seed — will test if this germinates. The level of germination has been low and variable from site to site. However, repeated sampling from the same sites is consistent. I have just started re-assaying samples.

One of the existing data sets I have been exploring is the 20 years of seed collection data that Joe Wright has. On Barro Colorado Island (a hill top made an island with the creation of the canal) is a 50 ha plot where every stem over 5 cm is recorded to species and a new census taken every five years. This is one of several now around the world that are the cornerstones of tropical ecology. In this plot there are 200 seed traps (mesh forming a basket) that are emptied every week and every fruit, flower and seed collected is identified to species level. 

I have been analysing the data for Saccharum spontaneum. Significant in itself as the seed is not produced on the island and so gives some indication of the distance the seed can travel. I am looking at this data in relation to the weather records. It is not staightfoward as the year to year variation in timing and amount is a product of both seed production and dispersal and capture on the island. These two things may depend on different things. My assessment of germination data will be helpful to them as well because part of the assessment of their and related work is working out how big gaps have to be in the forest before S. sponataneum can invade. Part of this will be seed deposition but knowing the fraction that is viable is another important parameter.

Well we have viable seed and in an experiment set up last week have demonstrated that it can germinate in the environment — so we will be following the fate of these seedlings over the next few months. Re the vegetative reproduction, S. spontaneum seems to be able to withstand drying of the stems a lot more than elephant and guinea grasses, the other introduced competitors. My four weeks of drying treatment gets planted tomorrow.

I have taken the bee observations reported last month a step further, caught some bees and given my colleague Kristin the pollen mass that they adhere to their legs to see if we can identify S.spont DNA in the pollen mass. There are too many of them spending too much time on the flowers for them not to collecting the material. The anthers are very easily accessible as they protrude from the spikelets. The bees have been identified by Simon Tierny, a fellow Australian. It is good to see something making good use of the spont — if in fact they are. Whether they are aiding pollination at all is another matter.

PHOTO CAPTION: Deanne and I  have made polyester bags to exclude pollen from developing inflorescences of S. spontaneum and smaller ones to collect the seed of Guinea grass, it shatters at maturation.

More from Graham in the next issue of eNews.



CRC SIIB Symposium 2010

 
We will hold our sixth and final CRC SIIB Symposium on Thursday 6 & Friday 7 May 2010 at Victoria Golf Club, Brisbane.

More

All our participants are requested to attend the Symposium so please mark the dates in your diary.   Further program and registration details will be made available closer to the date. For information on the venue, go to www.victoriagolfcomplex.com.


More

The first edition of 'Authorship News' was recently released. Those who register to Authorship News in November will go into the draw to win a $100 book voucher!

The first issue of Authorship News covered:
• Authorship Management Basics... authorship criteria
• Dear Suzanne... answers to your authorship dilemmas Authorder®
• Postcards... for your workplace
• What People are Saying... recent feedback Coming Soon ... what's around the corner for authorder®

If you would like to receive future issues of the newsletter and also be in the chance to win a $100 book voucher, make sure you sign up this month at www.authorder.com.


Events


All events are also published on the CRC SIIB website www.crcsugar.com/Events/tabid/144/Default.a

More

CRC SIIB Board Meetings

Participants meeting - 2:00pm 3 December 2009
8:30am 4 December 2009
8:30am 26 February 2010
Final CRC Board Meeting - 8:30am 3 June 2010

OECD-Genome Association-OZ09

Nov 9-12, 2009

The University of Western Australia, Perth. Towards the application of association mapping to plant genetic improvement.

The challenge of this conference is to provide plant breeders with a clear path towards the application of association mapping to plant genetic improvement. OECD invited speakers are international experts in molecular marker discovery, plant genetic mapping, new biometrical approaches to plant breeding, human genetics and animal breeding.
 

For more information go to:
http://www.oecd-genomeassociation-oz09.com


ComBio 2009

6–10 December 2009
Christchurch NZ, Convention Centre
http://www.uco.canterbury.ac.nz/conference/co
mbio09/


Plant and Animal Genome Conference

San Diego
9-13 January 2010

http://www.intl-pag.org/

includes:

Sugarcane Workshop — PAG

San Diego
Sunday am 10 January 2010

Sugarcane Genome Sequencing Discussions

San Diego
Sunday pm 10 January 2010

ISSCT — Veracruz Mexico

7-11 March 2010
http://issct.intnet.mu/mexicoxxviicong.htm



ASSCT 2010

11 - 14 May 2010
Bundaberg, Qld
http://www.assct.com.au